Reqwest is the most popular async HTTP client for Rust. It's built on tokio and hyper, with a high-level API for making requests. Connection pooling, redirects, timeouts, and TLS are handled automatically. I use the builder pattern to configure clients, and the ? operator with anyhow for error handling. For JSON APIs, .json() deserializes directly into your serde types. The client is Clone and internally uses an Arc, so you can share it across tasks cheaply. For retries, rate limiting, or custom middleware, I wrap it in a service struct. Reqwest strikes a good balance between convenience and performance, and it's battle-tested in production at scale.